I agree to the terms and conditions. Related conjugates and formulations. Reacts with: Mouse, Rat, Human, Recombinant fragment. WB: Klinked-Ub recombinant protein. HEk and HeLa cell lysate.
Mouse and rat brain lysate. IHC: Human kidney carcinoma tissue. Human tonsil tissue. Flow Cyt intra : HeLa cells. Upon delivery aliquot. Preservative: 0. Concentration information loading Associated products.
Recombinant Human Ubiquitin protein His tag ab Prestained Protein Ladder - Broad molecular weight kDa ab The Abpromise guarantee Our Abpromise guarantee covers the use of ab in the following tested applications. Function: Ubiquitin exists either covalently attached to another protein, or free unanchored. When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer monoubiquitin , a polymer linked via different Lys residues of the ubiquitin polyubiquitin chains or a linear polymer linked via the initiator Met of the ubiquitin linear polyubiquitin chains.
Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lyslinked may be involved in DNA repair; Lyslinked is involved in ERAD endoplasmic reticulum-associated degradation and in cell-cycle regulation; Lyslinked is involved in lysosomal degradation; Lyslinked is involved in kinase modification; Lyslinked is involved in protein degradation via the proteasome; Lyslinked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B.
Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free unanchored-polyubiquitin , it also has distinct roles, such as in activation of protein kinases, and in signaling. Similarity: Belongs to the ubiquitin family. Contains 3 ubiquitin-like domains. Predicted band size: 77 kDa. Flow cytometry protocols.
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